PDB ID: 1X97
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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FIR | (2r,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione | PoSSuM | |||
NAP | Nadp nicotinamide-adenine-dinucleotide phosphate | PoSSuM |
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Download interaction data: 1X97
Structure summary
Code : | 1X97 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Crystal structure of Aldose Reductase complexed with 2R4S (Stereoisomer of Fidarestat, 2S4S) | ||||||||||||
Release Data : | 2004-09-07 | ||||||||||||
Compound : |
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Authors : | El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A., Podjarny, A. | ||||||||||||
Keywords : | Eight strandard alpha/beta barrel, active site, the C-terminal end of the barrel, Oxidoreductase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.40 Å ) | ||||||||||||
Citation : |
High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
El-Kabbani, O.,Darmanin, C.,Oka, M.
et al.
PubMed: 15317464 |
Reaction
Chain : | A | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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UniProt : | P15121 (ALDR_HUMAN) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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