Brand  (β version)

PDB ID: 1X81

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Ligands
Code Name Style Show Link
JAN 6-[(S)-amino(4-chlorophenyl)(1-methyl-1h-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1h)-one PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1X81   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Farnesyl transferase structure of Jansen compound
Release Data : 2004-12-21
Compound :
mol_id molecule chains synonym
1 Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit A CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase alpha subunit, GGTase-I-alpha
ec: 2.5.1.58, 2.5.1.59
fragment: residues 55-369
mol_id molecule chains synonym
2 Protein farnesyltransferase beta subunit B CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta
ec: 2.5.1.58
fragment: residues 22-418
Source :
mol_id organism_scientific organism_common
1 Rattus norvegicus  (taxid:10116) Norway rat
mol_id organism_scientific organism_common
2 Rattus norvegicus  (taxid:10116) Norway rat
Authors : Li, Q., Claiborne, A., Li, T., Hasvold, L., Stoll, V.S., Muchmore, S., Jakob, C.G., Gu, W., Cohen, J., Hutchins, C., Frost, D., Rosenberg, S.H., Sham, H.L.
Keywords : fanesyltransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3.5 Å )
Citation :

Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.

Li, Q.,Claiborne, A.,Li, T.  et al.
(2004)  Bioorg.Med.Chem.Lett.  14 : 5367 - 5370

PubMed: 15454228
DOI: 10.1016/j.bmcl.2004.08.012

Reaction

Chain : A
UniProt : Q04631 (FNTA_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12657282, PubMed:18844669, PubMed:19219049, PubMed:22963166
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geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.59 PubMed:14609943, PubMed:19219049
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Chain : B
UniProt : Q02293 (FNTB_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:10673434, PubMed:18844669, PubMed:19219049, PubMed:19246009, PubMed:22963166
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