Het-PDB Navi2 (PDB: 1WZY)

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Ligands
Code	Name		Style	Show	Link
F29	1-allyl-5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1h-pyrazolo[3,4-C]pyridazin-3-amine				PoSSuM

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Download interaction data: 1WZY

Code :

1WZY PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative

Release Data :

2005-12-20

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 1	A	Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1
	ec: 2.7.1.37

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

Authors :

Kinoshita, T.

Keywords :

ERK2, inhibitor, kinase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative

Kinoshita, T.,Warizaya, M.,Ohori, M. et al.
(2006) Bioorg.Med.Chem.Lett. 16 : 55 - 58

Chain :

UniProt :

P28482 (MK01_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.24	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.24	-
	-	-

PDB ID: 1WZY