Brand  (β version)

PDB ID: 1W9U

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
0AR N-[N-[(4s)-4-azanyl-5-hydroxy-5-oxo-pentyl]carbamimidoyl]ethanamide
DPR D-proline
HSE L-homoserine
UN1 2-aminohexanedioic acid
Glycosylation
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Structure summary

Code : 1W9U   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Specificity and affnity of natural product cyclopentapeptide inhibitor Argadin against Aspergillus fumigatus chitinase
Release Data : 2004-11-17
Compound :
mol_id molecule chains
1 CHITINASE A,B
ec: 3.2.1.14
mol_id molecule chains
2 ARGADIN C,D
Source :
mol_id organism_scientific expression_system
1 ASPERGILLUS FUMIGATUS  (taxid:746128) ESCHERICHIA COLI  (taxid:469008)
atcc: 13073
expression_system_strain: BL21(DE3)
expression_system_variant: PLYSS
expression_system_plasmid: PGEX6P
mol_id organism_scientific
2 CLONOSTACHYS  (taxid:110564)
synthetic: yes
Authors : Rao, F.V., Houston, D.R., Boot, R.G., Aerts, J.M.F.G., Hodkinson, M., Adams, D.J., Shiomi, K., Omura, S., van Aalten, D.M.F.
Keywords : CHITINASE, ARGADIN, CYCLOPENTAPEPTIDE INHIBITORS, CHITINASE INHIBITORS, GLYCOSIDASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Specificity and Affinity of Natural Product Cyclopentapeptide Inhibitors Against Aspergillus Fumigatus, Human and Bacterial Chitinases

Rao, F.V.,Houston, D.R.,Boot, R.G.  et al.
(2005)  Chem.Biol.  12 : 65

PubMed: 15664516
DOI: 10.1016/J.CHEMBIOL.2004.10.013

Reaction

Chain : A, B
UniProt : Q873X9 (CHIB1_ASPFM)
Reaction: EC: Evidence:
Physiological Direction:
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. 3.2.1.14 PubMed:14523125, PubMed:15664516, PubMed:16096835, PubMed:16183021, PubMed:18975073
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