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PDB ID: 1W6U

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Ligands
Code Name Style Show Link
HXC Hexanoyl-coenzyme a PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1W6U   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of human DECR ternary complex
Release Data : 2004-10-28
Compound :
mol_id molecule chains synonym
1 2,4-DIENOYL-COA REDUCTASE, MITOCHONDRIAL PRECURSOR A,B,C,D 2,4-DIENOYL-COA REDUCTASE [NADPH], 4-ENOYL-COA REDUCTASE [NADPH]
ec: 1.3.1.34
other_details: COFACTOR (N) NADP SUBSTRATE (S) 2,4-HEXADIENOYL-COA
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
organelle: MITOCHONDRIAL
expression_system_strain: BL21(DE3)
expression_system_plasmid: PLM1
Authors : Alphey, M.S., Byres, E., Li, D., Hunter, W.N.
Keywords : DIENOYL COA-REDUCTASE, SHORT CHAIN DEHYDROGENASE, BETA-OXIDATION, NADP, OXIDOREDUCTASE, REDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Structure and Reactivity of Human Mitochondrial 2,4-Dienoyl-Coa Reductase: Enzyme-Ligand Interactions in a Distinctive Short-Chain Reductase Active Site

Alphey, M.S.,Yu, W.,Byres, E.  et al.
(2005)  J.Biol.Chem.  280 : 3068

PubMed: 15531764
DOI: 10.1074/JBC.M411069200

Reaction

Chain : A, B, C, D
UniProt : Q16698 (DECR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)- enoyl-CoA + NADP(+) 1.3.1.124 PubMed:15531764
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a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)- enoyl-CoA + NADP(+) 1.3.1.124 PubMed:15531764
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(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (3E)-hexenoyl-CoA + NADP(+) - PubMed:15531764
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