Brand  (β version)

PDB ID: 1VXR

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
VX O-ethylmethylphosphonic acid ester group PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 1VXR   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : O-ETHYLMETHYLPHOSPHONYLATED ACETYLCHOLINESTERASE OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)
Release Data : 1999-11-15
Compound :
mol_id molecule chains
1 PROTEIN (ACETYLCHOLINESTERASE) A
ec: 3.1.1.7
other_details: COMPLEXED WITH THE NERVE AGENT VX
Source :
mol_id organism_scientific organism_common
1 Torpedo californica  (taxid:7787) Pacific electric ray
organ: ELECTRIC ORGAN
tissue: ELECTROPLAQUE
cellular_location: MEMBRANE BOUND BY GPI ANCHOR
Authors : Millard, C.B., Koellner, G., Silman, I., Sussman, J.L.
Keywords : CHOLINESTERASE, ORGANOPHOSPHATE, SERINE HYDROLASE, CHEMICAL-WARFARE, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad

Millard, C.B.,Koellner, G.,Ordentlich, A.  et al.
(1999)  J.Am.Chem.Soc.  121 : 9883 - 9884

PubMed: -1
DOI: 10.1021/ja992704i

Reaction

Chain : A
UniProt : P04058 (ACES_TETCF)
Reaction: EC: Evidence:
Physiological Direction:
acetylcholine + H2O = acetate + choline + H(+) 3.1.1.7 -
-