Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
VX O-ethylmethylphosphonic acid ester group
MES 2-(N-morpholino)-ethanesulfonic acid
NAG N-acetyl-D-glucosamine
NDG 2-(acetylamino)-2-deoxy-a-D-glucopyranose
Code : 1VXR
Header : HYDROLASE
Title : O-ETHYLMETHYLPHOSPHONYLATED ACETYLCHOLINESTERASE OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)
Release Data : 1999-11-15
Compound :
mol_id molecule chains
1 PROTEIN (ACETYLCHOLINESTERASE) A
ec: 3.1.1.7
other_details: COMPLEXED WITH THE NERVE AGENT VX
Source :
mol_id organism_scientific organism_common
1 Torpedo californica  (taxid:7787) Pacific electric ray
organ: ELECTRIC ORGAN
tissue: ELECTROPLAQUE
cellular_location: MEMBRANE BOUND BY GPI ANCHOR
Authors : Millard, C.B., Koellner, G., Silman, I., Sussman, J.L.
Keywords : CHOLINESTERASE, ORGANOPHOSPHATE, SERINE HYDROLASE, CHEMICAL-WARFARE, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad

Millard, C.B.,Koellner, G.,Ordentlich, A.  et al.
(1999)  J.Am.Chem.Soc.  121 : 9883 - 9884

PubMed: -1
DOI: 10.1021/ja992704i

Chain : A
UniProt : P04058 (ACES_TETCF)
Reaction : Acetylcholine + H(2)O = choline + acetate.