Brand  (β version)

PDB ID: 1VSJ

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Ligands
Code Name Style Show Link
CD Cadmium ion PoSSuM
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid PoSSuM
Non-standard Residues
Code Name Show
OCY Hydroxyethylcysteine
Glycosylation
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Structure summary

Code : 1VSJ   PDBj   RCSB PDB   PDBe
Header : ENDONUCLEASE
Title : ASV INTEGRASE CORE DOMAIN WITH CD(II) COFACTORS
Release Data : 1997-05-15
Compound :
mol_id molecule chains
1 INTEGRASE A
fragment: CATALYTIC CORE DOMAIN, RESIDUES 1 - 4, 52 - 209
Source :
mol_id organism_scientific expression_system
1 Rous sarcoma virus (strain Schmidt-Ruppin)  (taxid:11889) Escherichia coli  (taxid:562)
strain: Schmidt-Ruppin
expression_system_plasmid: PRC23IN(52-207)
other_details: ORIGINAL VIRAL DNA CLONE\: JU ET AL., J. VIROL. 33\:1026-1033 (1980), ORIGINAL EXPRESSION CLONE TERRY ET AL., J. VIROL. 62\:2358-2365 (1988), EXPRESSION
Authors : Bujacz, G., Alexandratos, J., Wlodawer, A.
Keywords : ENDONUCLEASE, HYDROLASE, ENDORIBONUCLEASE, RNA-DIRECTED DNA POLYMERASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity.

Bujacz, G.,Alexandratos, J.,Wlodawer, A.  et al.
(1997)  J.Biol.Chem.  272 : 18161 - 18168

PubMed: 9218451
DOI: 10.1074/jbc.272.29.18161

Reaction

Chain : A
UniProt : P03354 (POL_RSVP)
Reaction: EC: Evidence:
Physiological Direction:
[Reverse transcriptase alpha-subunit]
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 		2.7.7.49 PROSITE- ProRule:PRU00405
-
[Reverse transcriptase alpha-subunit]
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 		2.7.7.7 PROSITE- ProRule:PRU00405
-
[Reverse transcriptase alpha-subunit]
Endonucleolytic cleavage to 5'-phosphomonoester. 		3.1.26.4 PROSITE-ProRule:PRU00408
-