Brand  (β version)

PDB ID: 1VSD

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Ligands
Code Name Style Show Link
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
Code Name Show
OCY Hydroxyethylcysteine
Glycosylation
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Modification
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Structure summary

Code : 1VSD   PDBj   RCSB PDB   PDBe
Header : ENDORIBONUCLEASE
Title : ASV INTEGRASE CORE DOMAIN WITH MG(II) COFACTOR AND HEPES LIGAND, HIGH MG CONCENTRATION FORM
Release Data : 1996-04-03
Compound :
mol_id molecule chains
1 INTEGRASE A
fragment: CATALYTIC CORE DOMAIN, RESIDUES 1 - 4, 52 - 209
other_details: CRYSTALS SOAKED IN 500 MILLIMOLAR MGCL2
Source :
mol_id organism_scientific expression_system
1 Rous sarcoma virus (strain Schmidt-Ruppin)  (taxid:11889) Escherichia coli  (taxid:562)
strain: Schmidt-Ruppin
expression_system_plasmid: PRC23IN(52-207)
other_details: ORIGINAL VIRAL DNA CLONE\: JU ET AL., J. VIROL. 33:1026-1033 (1980), ORIGINAL EXPRESSION CLONE\: TERRY ET AL., J. VIROL. 62:2358-2365 (1988), EXPRESSION CLONE FOR CORE\: KULKOSKY ET AL., J. VIROL. 206:448-456 (1995)
Authors : Bujacz, G., Jaskolski, M., Alexandratos, J., Wlodawer, A.
Keywords : HYDROLASE, ENDONUCLEASE, ENDORIBONUCLEASE
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations.

Bujacz, G.,Jaskolski, M.,Alexandratos, J.  et al.
(1996)  Structure  4 : 89 - 96

PubMed: 8805516
DOI: 10.1016/S0969-2126(96)00012-3

Reaction

Chain : A
UniProt : P03354 (POL_RSVP)
Reaction: EC: Evidence:
Physiological Direction:
[Reverse transcriptase alpha-subunit]
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 		2.7.7.49 PROSITE- ProRule:PRU00405
-
[Reverse transcriptase alpha-subunit]
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 		2.7.7.7 PROSITE- ProRule:PRU00405
-
[Reverse transcriptase alpha-subunit]
Endonucleolytic cleavage to 5'-phosphomonoester. 		3.1.26.4 PROSITE-ProRule:PRU00408
-