Brand  (β version)

PDB ID: 1VBD

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Ligands
Code Name Style Show Link
J78 (methylpyridazine piperidine propyloxyphenyl)ethylacetate PoSSuM
MYR Myristic acid PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1VBD   PDBj   RCSB PDB   PDBe
Header : VIRUS
Title : POLIOVIRUS (TYPE 1, MAHONEY STRAIN) COMPLEXED WITH R78206
Release Data : 1996-07-11
Compound :
mol_id molecule chains
1 POLIOVIRUS TYPE 1 MAHONEY 0
other_details: P1/MAHONEY
mol_id molecule chains
2 POLIOVIRUS TYPE 1 MAHONEY 1
other_details: P1/MAHONEY
mol_id molecule chains
3 POLIOVIRUS TYPE 1 MAHONEY 2
other_details: P1/MAHONEY
mol_id molecule chains
4 POLIOVIRUS TYPE 1 MAHONEY 3
other_details: P1/MAHONEY
mol_id molecule chains
5 POLIOVIRUS TYPE 1 MAHONEY 4
other_details: P1/MAHONEY
Source :
mol_id organism_scientific
1 Human poliovirus 1  (taxid:12081)
strain: Mahoney
other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY M. CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME
mol_id organism_scientific
2 Human poliovirus 1  (taxid:12081)
strain: Mahoney
cell_line: HELA
other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY M. CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME
mol_id organism_scientific
3 Human poliovirus 1  (taxid:12081)
strain: Mahoney
cell_line: HELA
other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY M. CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME
mol_id organism_scientific
4 Human poliovirus 1  (taxid:12081)
strain: Mahoney
cell_line: HELA
other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY M. CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME
mol_id organism_scientific
5 Human poliovirus 1  (taxid:12081)
strain: Mahoney
cell_line: HELA
other_details: P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY M. CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME
Authors : Grant, R.A., Hiremath, C.N., Filman, D.J., Syed, R., Andries, K., Hogle, J.M.
Keywords : VIRUS COAT PROTEIN, HYDROLASE, THIOL PROTEASE, Icosahedral virus, Virus
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design.

Grant, R.A.,Hiremath, C.N.,Filman, D.J.  et al.
(1994)  Curr.Biol.  4 : 784 - 797

PubMed: 7820548
DOI: 10.1016/S0960-9822(00)00176-7

Binding of the Antiviral Drug Win51711 to the Sabin Strain of Type 3 Poliovirus: Structural Comparison with Drug Binding in Rhinovirus 14

Hiremath, C.N.,Grant, R.A.,Filman, D.J.  et al.
(1995)  Acta Crystallogr.,Sect.D  51 : 473

Role of Conformational Transitions in Poliovirus Assembly and Cell Entry

Hogle, J.M.,Syed, R.,Fricks, C.E.  et al.
(1990)  New Aspects of Positive-Strand RNA Viruses  : 199

Structural Factors that Control Conformational Transitions and Serotype Specificity in Type 3 Poliovirus

Filman, D.J.,Syed, R.,Chow, M.  et al.
(1989)  Embo J.  8 : 1567

Myristylation of Picornavirus Capsid Protein Vp4 and its Structural Significance

Chow, M.,Newman, J.F.,Filman, D.  et al.
(1987)  Nature  327 : 482

Three-Dimensional Structure of Poliovirus at 2.9 A Resolution

Hogle, J.M.,Chow, M.,Filman, D.J.
(1985)  Science  229 : 1358

The Nucleotide Sequence of Poliovirus Type 3 Leon 12 A1B: Comparison with Poliovirus Type 1

Stanway, G.,Cann, A.J.,Hauptmann, R.  et al.
(1983)  Nucleic Acids Res.  11 : 5629

Reaction

Chain : 3
UniProt : P03300 (POLG_POL1M)
Reaction: EC: Evidence:
Physiological Direction:
[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539
-
[Protease 2A]
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 		3.4.22.29 PubMed:1649327
-
[Protein 2C]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 PubMed:19520852, PubMed:30231078, PubMed:7730315, PubMed:8385138
-
[Protease 3C]
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 		3.4.22.28 PROSITE-ProRule:PRU01222, PubMed:8097606
-