Het-PDB Navi2 (PDB: 1V79)

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Ligands
Code	Name		Style	Show	Link
FR7	1-{(1r,2s)-1-[2-(2,3,-dichlorophenyl)ethyl]-2-hydroxypropyl}-1h-imidazole-4-carboxamide				PoSSuM
ZN	Zinc ion				PoSSuM

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Download interaction data: 1V79

Code :

1V79 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structures of adenosine deaminase complexed with potent inhibitors

Release Data :

2004-12-21

Compound :

mol_id	molecule	chains	synonym
1	Adenosine deaminase	A	Adenosine aminohydrolase
	ec: 3.5.4.4

Source :

mol_id	organism_scientific	organism_common
1	Bos taurus (taxid:9913)	Cattle

Authors :

Kinoshita, T.

Keywords :

beta barrel, zinc, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.5 Å )

Citation :

Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors

Terasaka, T.,Okumura, H.,Tsuji, K. et al.
(2004) J.Med.Chem. 47 : 2728 - 2731

Chain :

UniProt :

P56658 (ADA_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
adenosine + H2O + H(+) = inosine + NH4(+)	3.5.4.4	UniProtKB:P00813
adenosine + H2O + H(+) = inosine + NH4(+)	left-to-right	UniProtKB:P00813
2'-deoxyadenosine + H2O + H(+) = 2'-deoxyinosine + NH4(+)	3.5.4.4	UniProtKB:P00813
2'-deoxyadenosine + H2O + H(+) = 2'-deoxyinosine + NH4(+)	left-to-right	UniProtKB:P00813
cordycepin + H2O + H(+) = 3'-deoxyinosine + NH4(+)	-	UniProtKB:P00813
cordycepin + H2O + H(+) = 3'-deoxyinosine + NH4(+)	left-to-right	UniProtKB:P00813
Cofactor:	Evidence:	Note:
Zn(2+)	ECO:0000269 \| PubMed:12554940 ECO:0000269 \| PubMed:14709046 ECO:0000269 \| PubMed:15213224 ECO:0000269 \| PubMed:16033254	Binds 1 zinc ion per subunit.

PDB ID: 1V79