Brand  (β version)

PDB ID: 1V79

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Color scheme of protein:

Code Name Style Show Link
FR7 1-{(1r,2s)-1-[2-(2,3,-dichlorophenyl)ethyl]-2-hydroxypropyl}-1h-imidazole-4-carboxamide PoSSuM
ZN Zinc ion PoSSuM

Select hetatm:   

Select hetatm:   

Select chain:  

Data format:   

Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1V79   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structures of adenosine deaminase complexed with potent inhibitors
Release Data : 2004-12-21
Compound :
mol_id molecule chains synonym
1 Adenosine deaminase A Adenosine aminohydrolase
ec: 3.5.4.4
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
Authors : Kinoshita, T.
Keywords : beta barrel, zinc, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors

Terasaka, T.,Okumura, H.,Tsuji, K.  et al.
(2004)  J.Med.Chem.  47 : 2728 - 2731

PubMed: 15139750
DOI: 10.1021/jm0499559

Reaction

Chain : A
UniProt : P56658 (ADA_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
adenosine + H2O + H(+) = inosine + NH4(+) 3.5.4.4 UniProtKB:P00813
left-to-right
2'-deoxyadenosine + H2O + H(+) = 2'-deoxyinosine + NH4(+) 3.5.4.4 UniProtKB:P00813
left-to-right
cordycepin + H2O + H(+) = 3'-deoxyinosine + NH4(+) - UniProtKB:P00813
left-to-right
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:12554940
ECO:0000269 | PubMed:14709046
ECO:0000269 | PubMed:15213224
ECO:0000269 | PubMed:16033254
Binds 1 zinc ion per subunit.