Brand  (β version)

PDB ID: 1V54

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Ligands
Code Name Style Show Link
CDL Cardiolipin PoSSuM
CHD Cholic acid PoSSuM
CU Copper (II) ion PoSSuM
CUA Dinuclear copper ion PoSSuM
HEA Heme-a PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
PEK (1s)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(stearoyloxy)methyl]ethyl (5e,8e,11e,14e)-icosa-5,8,11,14-tetraenoate PoSSuM
PGV (1r)-2-{[{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11e)-octadec-11-enoate PoSSuM
PSC (7r,17e,20e)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosa-17,20-dien-1-aminium 4-oxide PoSSuM
TGL Tristearoylglycerol PoSSuM
UNX Unknown atom or ion PoSSuM
ZN Zinc ion PoSSuM
DMU Decyl-beta-D-maltopyranoside PoSSuM
Non-standard Residues
Code Name Show
FME N-formylmethionine
SAC N-acetyl-serine
TPO Phosphothreonine
Glycosylation
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Modification
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Structure summary

Code : 1V54   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Bovine heart cytochrome C oxidase at the fully oxidized state
Release Data : 2003-12-23
Compound :
mol_id molecule chains
1 Cytochrome c oxidase polypeptide I A,N
ec: 1.9.3.1
mol_id molecule chains
2 Cytochrome c oxidase polypeptide II B,O
ec: 1.9.3.1
mol_id molecule chains
3 Cytochrome c oxidase polypeptide III C,P
ec: 1.9.3.1
mol_id molecule chains synonym
4 Cytochrome c oxidase subunit IV isoform 1 D,Q COX IV-1, Cytochrome c oxidase polypeptide IV
ec: 1.9.3.1
mol_id molecule chains
5 Cytochrome c oxidase polypeptide Va E,R
ec: 1.9.3.1
mol_id molecule chains synonym
6 Cytochrome c oxidase polypeptide Vb F,S VI
ec: 1.9.3.1
mol_id molecule chains synonym
7 Cytochrome c oxidase polypeptide VIa-heart G,T COXVIAH, Polypeptide VIb
ec: 1.9.3.1
mol_id molecule chains synonym
8 Cytochrome c oxidase polypeptide VIb H,U AED
ec: 1.9.3.1
mol_id molecule chains synonym
9 Cytochrome c oxidase polypeptide VIc I,V STA
ec: 1.9.3.1
mol_id molecule chains synonym
10 Cytochrome c oxidase polypeptide VIIa-heart J,W Cytochrome c oxidase subunit VIIa-H, COX VIIa-M, VIIIC
ec: 1.9.3.1
mol_id molecule chains synonym
11 Cytochrome c oxidase polypeptide VIIb K,X IHQ
ec: 1.9.3.1
mol_id molecule chains synonym
12 Cytochrome c oxidase polypeptide VIIc L,Y VIIIA
ec: 1.9.3.1
mol_id molecule chains synonym
13 Cytochrome c oxidase polypeptide VIII-heart M,Z VIIIb, IX
ec: 1.9.3.1
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
3 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
4 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
5 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
6 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
7 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
8 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
9 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
10 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
11 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
12 Bos taurus  (taxid:9913) Cattle
tissue: heart
mol_id organism_scientific organism_common
13 Bos taurus  (taxid:9913) Cattle
tissue: heart
Authors : Tsukihara, T., Shimokata, K., Katayama, Y., Shimada, H., Muramoto, K., Aoyama, H., Mochizuki, M., Shinzawa-Itoh, K., Yamashita, E., Yao, M., Ishimura, Y., Yoshikawa, S.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process.

Tsukihara, T.,Shimokata, K.,Katayama, Y.  et al.
(2003)  Proc.Natl.Acad.Sci.Usa  100 : 15304 - 15309

PubMed: 14673090
DOI: 10.1073/pnas.2635097100

Reaction

Chain : A, N
UniProt : P00396 (COX1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)- [cytochrome c] + 2 H2O + 4 H(+)(out) 7.1.1.9 UniProtKB:P00401
left-to-right
Cofactor: Evidence: Note:
heme ECO:0000269 | PubMed:20385840
ECO:0000269 | PubMed:2165784
ECO:0000269 | PubMed:8638158
Binds 2 heme A groups non-covalently per subunit.
Cu cation ECO:0000269 | PubMed:20385840
ECO:0000269 | PubMed:2165784
ECO:0000269 | PubMed:8638158
Binds a copper B center.
Chain : B, O
UniProt : P68530 (COX2_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)- [cytochrome c] + 2 H2O + 4 H(+)(out) 7.1.1.9 UniProtKB:P00410
left-to-right
Cofactor: Evidence: Note:
Cu cation ECO:0000269 | PubMed:20385840
ECO:0000269 | PubMed:8638158
Binds a dinuclear copper A center per subunit.
Chain : C, P
UniProt : P00415 (COX3_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)- [cytochrome c] + 2 H2O + 4 H(+)(out) 7.1.1.9 UniProtKB:P00420
left-to-right
Chain : D, Q
UniProt : P00423 (COX41_BOVIN)
Reaction : -
Chain : E, R
UniProt : P00426 (COX5A_BOVIN)
Reaction : -
Chain : F, S
UniProt : P00428 (COX5B_BOVIN)
Reaction : -
Chain : G, T
UniProt : P07471 (CX6A2_BOVIN)
Reaction : -
Chain : H, U
UniProt : P00429 (CX6B1_BOVIN)
Reaction : -
Chain : I, V
UniProt : P04038 (COX6C_BOVIN)
Reaction : -
Chain : J, W
UniProt : P07470 (CX7A1_BOVIN)
Reaction : -
Chain : K, X
UniProt : P13183 (COX7B_BOVIN)
Reaction : -
Chain : L, Y
UniProt : P00430 (COX7C_BOVIN)
Reaction : -
Chain : M, Z
UniProt : P10175 (COX8B_BOVIN)
Reaction : -