Het-PDB Navi2 (PDB: 1UNH)

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Ligands
Code	Name		Style	Show	Link
IXM	(z)-1h,1'H-[2,3']biindolylidene-3,2'-dione-3-oxime				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1UNH

Code :

1UNH PDBj RCSB PDB PDBe

Header :

CELL CYCLE

Title :

Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.

Release Data :

2004-11-10

Compound :

mol_id	molecule	chains	synonym
1	CYCLIN-DEPENDENT KINASE 5	A,B	TAU PROTEIN KINASE II, TPKII CATALYTIC, SERINE/THREONINE PROTEIN KINASE PSSALRE, CYCLIN-DEPENDENT KINASE 5
	ec: 2.7.11.22 mutation: YES

mol_id	molecule	chains	synonym
2	CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1	D,E	CDK5 ACTIVATOR 1, CYCLIN-DEPENDENT KINASE 5 REGULATORY SUBUNIT 1, TAU PROTEIN KINASE II, TPKII REGULATORY SUBUNIT, P23, P25, P35NCK5A
	fragment: RESIDUES 100-307

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_cell_line: SF9 expression_system_vector_type: BACULOVIRUS expression_system_plasmid: PFASTBAC

mol_id	organism_scientific	organism_common	expression_system
2	HOMO SAPIENS (taxid:9606)	HUMAN	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_cell_line: SF9 expression_system_vector_type: BACULOVIRUS expression_system_plasmid: PFASTBAC

Authors :

Mapelli, M., Crovace, C., Massimiliano, L., Musacchio, A.

Keywords :

CELL CYCLE, NEURODEGENERATIVE DISEASES, INDIRUBIN

Exp. method :

X-RAY DIFFRACTION ( 2.35 Å )

Citation :

Mechanism of Cdk5/P25 Binding by Cdk Inhibitors

Mapelli, M.,Massimilinao, L.,Crovace, C. et al.
(2005) J.Med.Chem. 48 : 671

PDB ID: 1UNH