Brand  (β version)

PDB ID: 1UK0

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Ligands
Code Name Style Show Link
FRM 2-{3-[4-(4-fluorophenyl)-3,6-dihydro-1(2h)-pyridinyl]propyl}-8-methyl-4(3h)-quinazolinone PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1UK0   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor
Release Data : 2004-01-27
Compound :
mol_id molecule chains synonym
1 Poly [ADP-ribose] polymerase-1 A,B poly(ADP-ribose) polymerase, PARP-1, ADPRT, NAD(+) ADP-ribosyltransferase-1, Poly[ADP-ribose] synthetase-1
ec: 2.4.2.30
fragment: catalytic domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector_type: plasmid
expression_system_plasmid: pGEX4T-2
Authors : Kinoshita, T.
Keywords : Protein-inhibitor complex, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3 Å )
Citation :

Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase.

Kinoshita, T.,Nakanishi, I.,Warizaya, M.  et al.
(2004)  Febs Lett.  556 : 43 - 46

PubMed: 14706823
DOI: 10.1016/S0014-5793(03)01362-0

Reaction

Chain : A, B
UniProt : P09874 (PARP1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+). 2.4.2.30 PubMed:18172500, PubMed:19764761, PubMed:25043379, PubMed:26344098, PubMed:28190768, PubMed:32358582, PubMed:33683197, PubMed:7852410
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L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D- ribosyl)-L-seryl-[protein] - PubMed:27067600, PubMed:27256882, PubMed:32028527, PubMed:33186521, PubMed:33683197, PubMed:34210965, PubMed:34625544, PubMed:29954836
left-to-right PubMed:27067600, PubMed:27256882, PubMed:32028527, PubMed:33186521, PubMed:33683197, PubMed:34210965, PubMed:34625544, PubMed:29954836
L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide - PubMed:19764761, PubMed:25043379, PubMed:35460603
left-to-right
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - PubMed:19764761, PubMed:25043379, PubMed:27256882
left-to-right
L-tyrosyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D- ribosyl)-L-tyrosyl-[protein] - PubMed:29954836, PubMed:30257210
left-to-right PubMed:29954836, PubMed:30257210
L-histidyl-[protein] + NAD(+) = H(+) + N(tele)-(ADP-D- ribosyl)-L-histidyl-[protein] + nicotinamide - PubMed:35393539
left-to-right