Brand  (β version)

PDB ID: 1U67

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Ligands
Code Name Style Show Link
ACD Arachidonic acid PoSSuM
COH Protoporphyrin ix containing co PoSSuM
BOG Octyl beta-D-glucopyranoside PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
NDG 2-acetamido-2-deoxy-alpha-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 1U67   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of Arachidonic Acid Bound to a Mutant of Prostagladin H Synthase-1 that Forms Predominantly 11-HPETE.
Release Data : 2004-09-07
Compound :
mol_id molecule chains synonym
1 Prostaglandin G/H synthase 1 precursor A Cyclooxygenase-1, COX-1, Prostaglandin-endoperoxide synthase 1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1
ec: 1.14.99.1
mutation: V349A,W387F
Source :
mol_id organism_scientific organism_common expression_system
1 Ovis aries  (taxid:9940) Sheep Spodoptera frugiperda  (taxid:7108)
gene: PTGS1, COX1
expression_system_common: Fall armyworm
expression_system_strain: sf21
expression_system_vector_type: baculovirus
expression_system_vector: pfastbac-htoCOX-1
Authors : Harman, C.A., Rieke, C.J., Garavito, R.M., Smith, W.L.
Keywords : cyclooxgenase, arachidonic acid, heme, eicosanoid, 11-HETE, COX-1, COX-2, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 3.1 Å )
Citation :

Crystal structure of arachidonic Acid bound to a mutant of prostaglandin endoperoxide h synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic Acid.

Harman, C.A.,Rieke, C.J.,Garavito, R.M.  et al.
(2004)  J.Biol.Chem.  279 : 42929 - 42935

PubMed: 15292194
DOI: 10.1074/jbc.M403013200

Reaction

Chain : A
UniProt : P05979 (PGH1_SHEEP)
Reaction: EC: Evidence:
Physiological Direction:
(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2 1.14.99.1 PubMed:7947975
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(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2 - PubMed:7947975
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AH2 + prostaglandin G2 = A + H2O + prostaglandin H2 - PubMed:7947975
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O - PubMed:9448728
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