Brand  (β version)

PDB ID: 1U65

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Ligands
Code Name Style Show Link
CP0 (4s)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1h-pyrano[3',4':6,7]indolizino[1,2-B]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate PoSSuM
IOD Iodide ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
FUC Alpha-L-fucopyranose
FUL Beta-L-fucopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 1U65   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Ache W. CPT-11
Release Data : 2005-07-19
Compound :
mol_id molecule chains synonym
1 Acetylcholinesterase A AChE
ec: 3.1.1.7
Source :
mol_id organism_scientific organism_common
1 Torpedo californica  (taxid:7787) Pacific electric ray
Authors : Harel, M., Hyatt, J.L., Brumshtein, B., Morton, C.L., Wadkins, R.W., Silman, I., Sussman, J.L., Potter, P.M., Israel Structural Proteomics Center (ISPC)
Keywords : torpedo ache, anticancer prodrug CPT-11, Israel Structural Proteomics Center, ISPC, Structural Genomics, Hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.61 Å )
Citation :

The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action

Harel, M.,Hyatt, J.L.,Brumshtein, B.  et al.
(2005)  Mol.Pharmacol.  67 : 1874 - 1881

PubMed: 15772291
DOI: 10.1124/mol.104.009944

Reaction

Chain : A
UniProt : P04058 (ACES_TETCF)
Reaction: EC: Evidence:
Physiological Direction:
acetylcholine + H2O = acetate + choline + H(+) 3.1.1.7 -
-