Brand  (β version)

PDB ID: 1TV6

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Ligands
Code Name Style Show Link
CP9 3-[4-(2-methyl-imidazo[4,5-C]pyridin-1-yl)benzyl]-3h-benzothiazol-2-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1TV6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : HIV-1 Reverse Transcriptase Complexed with CP-94,707
Release Data : 2004-07-20
Compound :
mol_id molecule chains
1 reverse transcriptase p66 subunit A
ec: 2.7.7.4
mol_id molecule chains
2 reverse transcriptase p51 subunit B
ec: 2.7.7.4
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus type 1 BH10  (taxid:11678) Escherichia coli  (taxid:562)
gene: POL
expression_system_strain: JM109
expression_system_vector_type: plasmid
expression_system_plasmid: pKRT
mol_id organism_scientific expression_system
2 Human immunodeficiency virus type 1 BH10  (taxid:11678) Escherichia coli  (taxid:562)
gene: POL
expression_system_strain: JM109
expression_system_vector_type: plasmid
expression_system_plasmid: pKRT
Authors : Pata, J.D., Stirtan, W.G., Goldstein, S.W., Steitz, T.A.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant RTs resistant to other non-nucleoside inhibitors

Pata, J.D.,Stirtan, W.G.,Goldstein, S.W.  et al.
(2004)  Proc.Natl.Acad.Sci.USA  101 : 10548 - 10553

PubMed: 15249669
DOI: 10.1073/pnas.0404151101

Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1

Smerdon, S.J.,Jaeger, J.,Wang, J.  et al.
(1994)  Proc.Natl.Acad.Sci.USA  91 : 3911 - 3915

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

Kohlstaedt, L.A.,Wang, J.,Friedman, J.M.  et al.
(1992)  Science  256 : 1783 - 1790

Reaction

Chain : B
UniProt : P03366 (POL_HV1B1)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275
-
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 ECO:0000250
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[Reverse transcriptase/ribonuclease H]
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 		3.1.26.13 PubMed:2476069
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[Reverse transcriptase/ribonuclease H]
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 		2.7.7.49 PROSITE- ProRule:PRU00405, PubMed:2476069
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[Reverse transcriptase/ribonuclease H]
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 		2.7.7.7 PROSITE- ProRule:PRU00405, PubMed:2476069
-