Het-PDB Navi2 (PDB: 1TUM)

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Ligands
Code	Name	Link
APC	Diphosphomethylphosphonic acid adenosyl ester	PoSSuM
CON	Cobalt tetraammine ion	PoSSuM
MG	Magnesium ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1TUM

Code :

1TUM PDBj RCSB PDB PDBe

Header :

MUTATOR PROTEIN

Title :

MUTT PYROPHOSPHOHYDROLASE-METAL-NUCLEOTIDE-METAL COMPLEX, NMR, 16 STRUCTURES

Release Data :

1997-05-15

Compound :

mol_id	molecule	chains	synonym
1	MUTATOR MUTT PROTEIN	A	MUTTQC, DGTP PYROPHOSPHOHYDROLASE, 7,8-DIHYDRO-8-OXOGUANINE-TRIPHOSPHATASE
	ec: 3.6.1.- other_details: MUTT-MG(2+)-AMPCPP-MG(2+) COMPLEX

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	strain: K12-I7023 expression_system_strain: HMS174 (DE3) expression_system_plasmid: PET MUTT, T7 PROMOTER expression_system_gene: MUTT

Authors :

Lin, J., Abeygunawardana, C., Frick, D.N., Bessman, M.J., Mildvan, A.S.

Keywords :

MUTATOR PROTEIN, QUATERNARY COMPLEX, NUCLEOSIDE TRIPHOSPHATE PYROPHOSPHOHYDROLASE, MUTT PYROPHOSPHOHYDROLASE-METAL-SUBSTRATE ANALOG COMPLEX

Exp. method :

SOLUTION NMR

Citation :

Solution structure of the quaternary MutT-M2+-AMPCPP-M2+ complex and mechanism of its pyrophosphohydrolase action.

Lin, J.,Abeygunawardana, C.,Frick, D.N. et al.
(1997) Biochemistry 36 : 1199 - 1211

NMR Studies of the Conformations and Location of Nucleotides Bound to the E.Coli Mutt Enzyme

Frick, D.N.,Weber, D.J.,Abeygunawardana, C. et al.
(1995) Biochemistry 34 : 5577

Solution Structure of the Mutt Enzyme, a Nucleoside Triphosphate Pyrophosphohydrolase

Abeygunawardana, C.,Weber, D.J.,Gittis, A.G. et al.
(1995) Biochemistry 34 : 14997

Chain :

UniProt :

P08337 (MUTT_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)	3.6.1.55	PubMed:1309939, PubMed:15850400, PubMed:23481913, PubMed:9311918
8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)	-
8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate + H(+)	-	PubMed:15850400, PubMed:23481913, PubMed:9311918
8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate + H(+)	-	PubMed:15850400, PubMed:23481913, PubMed:9311918
8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate	-	PubMed:15850400
8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate	-	PubMed:15850400
8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate	-	PubMed:15850400
8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate	-	PubMed:15850400

PDB ID: 1TUM