Brand  (β version)

PDB ID: 1TU6

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Ligands
Code Name Style Show Link
FSP [1-(4-fluorobenzyl)cyclobutyl]methyl (1s)-1-[oxo(1h-pyrazol-5-ylamino)acetyl]pentylcarbamate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1TU6   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Cathepsin K complexed with a ketoamide inhibitor
Release Data : 2004-09-21
Compound :
mol_id molecule chains synonym
1 Cathepsin K A,B Cathepsin O, Cathepsin X, Cathepsin O2
ec: 3.4.22.38
fragment: cathepsin K: mature form (residues 115-329)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CTSK, CTSO, CTSO2
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
expression_system_vector: pFastbac
Authors : Barrett, D.G., Catalano, J.G., Deaton, D.N., Hassell, A.M., Long, S.T., Miller, A.B., Miller, L.R., Shewchuk, L.M., Wells-Knecht, K.J., Wright, L.L.
Keywords : catk, cysteine protease, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with improved pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions

Barrett, D.G.,Catalano, J.G.,Deaton, D.N.  et al.
(2004)  BIOORG.MED.CHEM.LETT.  14 : 4897 - 4902

PubMed: 15341947
DOI: 10.1016/j.bmcl.2004.07.031

Reaction

Chain : A, B
UniProt : P43235 (CATK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg. 3.4.22.38 -
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