Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
BME Beta-mercaptoethanol
F89 S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo(f)quinazolin-9-yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid
UMP 2'-deoxyuridine 5'-monophosphate
Modified Residues
Code Name Link
FMT Formic acid
Code : 1TSD
Header : TRANSFERASE (METHYLTRANSFERASE)
Title : THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89
Release Data : 1996-01-29
Compound :
mol_id molecule chains
1 THYMIDYLATE SYNTHASE A,B
ec: 2.1.1.45
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
Authors : Weichsel, A., Montfort, W.R.
Keywords : DUMP, 1843U89, TRANSFERASE (METHYLTRANSFERASE)
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89.

Weichsel, A.,Montfort, W.R.
(1995)  Nat.Struct.Biol.  2 : 1095 - 1101

PubMed: 8846221
DOI: 10.1038/nsb1295-1095

Promotion of Purine Nucleotide Binding to Thymidylate Synthase by a Potent Folate Analogue Inhibitor, 1843U89

Weichsel, A.,Montfort, W.R.,Ciesla, J.  et al.
(1995)  Proc.Natl.Acad.Sci.USA  92 : 3493

Structure, Multiple Site Binding, and Segmental Accommodation in Thymidylate Synthase on Binding Dump and an Anti-Folate

Montfort, W.R.,Perry, K.M.,Fauman, E.B.  et al.
(1990)  Biochemistry  29 : 6964

Chain : A, B
UniProt : P00470 (multiple entry names are found)
Reaction : -