Het-PDB Navi2 (PDB: 1TQ9)

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Ligands
Code	Name		Style	Show	Link
CPA	2'-deoxycytidine-2'-deoxyadenosine-3',5'-monophosphate				PoSSuM

Non-standard Residues
Code	Name	Show
YCM	S-(2-amino-2-oxoethyl)-L-cysteine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1TQ9

Code :

1TQ9 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE

Release Data :

2004-09-14

Compound :

mol_id	molecule	chains	synonym
1	Ribonuclease, seminal	A,B	pancreatic type ribonuclease, Seminal RNase, S-RNase, Ribonuclease BS-1
	ec: 3.1.27.5

Source :

mol_id	organism_scientific	organism_common
1	Bos taurus (taxid:9913)	Cattle

Authors :

Sica, F., Di Fiore, A., Merlino, A., Mazzarella, L.

Keywords :

Protein-dinucleotide complex, Cytotoxic action, Hydrolase

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Structure and Stability of the Non-covalent Swapped Dimer of Bovine Seminal Ribonuclease: AN ENZYME TAILORED TO EVADE RIBONUCLEASE PROTEIN INHIBITOR

Sica, F.,Di Fiore, A.,Merlino, A. et al.
(2004) J.Biol.Chem. 279 : 36753 - 36760

PubMed: 15192098
DOI: 10.1074/jbc.M405655200

Bovine seminal ribonuclease: structure at 1.9 A resolution

Mazzarella, L.,Capasso, S.,Demasi, D. et al.
(1993) Acta Crystallogr.,Sect.D 49 : 389 - 402

DOI: 10.1107/S0907444993003403

Population shift vs induced fit: the case of bovine seminal ribonuclease swapping dimer

Merlino, A.,Vitagliano, L.,Sica, F. et al.
(2004) Biopolymers 73 : 689 - 695

PubMed: 15048772
DOI: 10.1002/bip.20016

Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2',5')adenosine

Vitagliano, L.,Adinolfi, S.,Riccio, A. et al.
(1998) Protein Sci. 7 : 1691 - 1699

PubMed: 10082366

A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease

Vitagliano, L.,Adinolfi, S.,Sica, F. et al.
(1999) J.Mol.Biol. 293 : 569 - 577

PubMed: 10543951
DOI: 10.1006/jmbi.1999.3158

The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative

Sica, F.,Di Fiore, A.,Zagari, A. et al.
(2003) Proteins 52 : 263 - 271

PubMed: 12833549
DOI: 10.1002/prot.10407

Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease

Berisio, R.,Sica, F.,De Lorenzo, C. et al.
(2003) FEBS Lett. 554 : 105 - 110

PubMed: 14596923
DOI: 10.1016/S0014-5793(03)01114-1

Swapping structural determinants of ribonucleases: an energetic analysis of the hinge peptide 16-22

Mazzarella, L.,Vitagliano, L.,Zagari, A.
(1995) Proc.Natl.Acad.Sci.USA 92 : 3799 - 3803

PubMed: 7731986
DOI: 10.1073/pnas.92.9.3799

Chain :

A, B

UniProt :

P00669 (RNS_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].	4.6.1.18	PubMed:4664228
	-	PubMed:4664228
an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].	4.6.1.18	PubMed:4664228
	-	PubMed:4664228

PDB ID: 1TQ9

Hetero Atom Contents

Structure summary

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