Brand  (β version)

PDB ID: 1TN7

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Ligands
Code Name Style Show Link
ACY Acetic acid PoSSuM
FII [(3,7,11-trimethyl-dodeca-2,6,10-trienyloxycarbamoyl)-methyl]-phosphonic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1TN7   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Protein Farnesyltransferase Complexed with a TC21 Peptide Substrate and a FPP Analog at 2.3A Resolution
Release Data : 2004-11-02
Compound :
mol_id molecule chains synonym
1 Protein farnesyltransferase alpha subunit A CAAX farnesyltransferase alpha subunit, FTase-alpha
ec: 2.5.1.58
mol_id molecule chains synonym
2 Protein farnesyltransferase beta subunit B CAAX farnesyltransferase beta subunit, FTase-beta
ec: 2.5.1.58
mol_id molecule chains
3 Fusion protein C
other_details: Consist of transforming protein p21B (KKSKTK) and the C-terminal CaaX motif of the Ras-related protein TC21 (CVIF)
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Spodoptera frugiperda  (taxid:7108)
gene: FNTA
expression_system_common: Fall armyworm
expression_system_vector_type: Baculovirus
mol_id organism_scientific organism_common expression_system
2 Rattus norvegicus  (taxid:10116) Norway rat Spodoptera frugiperda  (taxid:7108)
gene: FNTB
expression_system_common: Fall armyworm
expression_system_vector_type: Baculovirus
mol_id organism_scientific
3
synthetic: yes
other_details: the fusion protein was chemically synthesized
Authors : Reid, T.S., Terry, K.L., Casey, P.J., Beese, L.S.
Keywords : FTase, farnesyltransferase, farnesyl transferase, prenyltransferase, CaaX, TC21, lipid modification, prenylation, substrate selectivity, transferase
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.

Reid, T.S.,Terry, K.L.,Casey, P.J.  et al.
(2004)  J.Mol.Biol.  343 : 417 - 433

PubMed: 15451670
DOI: 10.1016/j.jmb.2004.08.056

Reaction

Chain : A
UniProt : Q04631 (FNTA_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12657282, PubMed:18844669, PubMed:19219049, PubMed:22963166
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geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.59 PubMed:14609943, PubMed:19219049
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Chain : B
UniProt : Q02293 (FNTB_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:10673434, PubMed:18844669, PubMed:19219049, PubMed:19246009, PubMed:22963166
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