Het-PDB Navi2 (PDB: 1TMB)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
0FL	3-amino-N-formyl-L-alanine
0MG	Amino{[(4s)-4-amino-5-carboxy-5-oxopentyl]amino}methaniminium
DPN	D-phenylalanine
TYS	O-sulfo-L-tyrosine
VLT	(2e,4s)-4-amino-5-(4-hydroxyphenyl)pent-2-enoic acid

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group

Download interaction data: 1TMB

Code :

1TMB PDBj RCSB PDB PDBe

Header :

HYDROLASE/hydrolase inhibitor

Title :

MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A

Release Data :

1994-01-31

Compound :

mol_id	molecule	chains
1	ALPHA-THROMBIN (SMALL SUBUNIT)	L
	ec: 3.4.21.5

mol_id	molecule	chains
2	ALPHA-THROMBIN (LARGE SUBUNIT)	H
	ec: 3.4.21.5

mol_id	molecule	chains
3	HIRUGEN	I

mol_id	molecule	chains
4	cyclotheonamide A	T

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific
3
	synthetic: yes

mol_id	organism_scientific	organism_common
4	Theonella sp. (taxid:73791)	Sponges

Authors :

Qiu, X., Padmanabhan, K.P., Maryanoff, B.E., Tulinsky, A.

Keywords :

SERINE PROTEINASE, HYDROLASE-hydrolase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.

Maryanoff, B.E.,Qiu, X.,Padmanabhan, K.P. et al.
(1993) Proc.Natl.Acad.Sci.USA 90 : 8048 - 8052

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

PDB ID: 1TMB