Brand  (β version)

PDB ID: 1TLS

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Ligands
Code Name Style Show Link
C2F 5-methyl-5,6,7,8-tetrahydrofolic acid PoSSuM
UFP 5-fluoro-2'-deoxyuridine-5'-monophosphate PoSSuM
Non-standard Residues
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CXM N-carboxymethionine
Glycosylation
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Structure summary

Code : 1TLS   PDBj   RCSB PDB   PDBe
Header : METHYLTRANSFERASE
Title : THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH FDUMP AND METHYLENETETRAHYDROFOLATE
Release Data : 1997-07-07
Compound :
mol_id molecule chains
1 THYMIDYLATE SYNTHASE A,B
ec: 2.1.1.45
other_details: TERNARY COMPLEX WITH FDUMP (INHIBITOR) AND METHYLENETETRAHYDROFOLATE (COFACTOR)
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_strain: XAC 25
expression_system_plasmid: BLUESCRIPT PLASMID SK+
other_details: STRAIN LACKS HOST THYMIDYLATE SYNTHASE GENE
Authors : Hyatt, D.C., Maley, F., Montfort, W.R.
Keywords : TRANSFERASE, METHYLTRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.6 Å )
Citation :

Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.

Hyatt, D.C.,Maley, F.,Montfort, W.R.
(1997)  Biochemistry  36 : 4585 - 4594

PubMed: 9109668
DOI: 10.1021/bi962936j

Reaction

Chain : A, B
UniProt : P00470 (multiple entry names are found)
Reaction : -