PDB ID: 1TLC
Hetero Atom Contents
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Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
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DGP | 2'-deoxyguanosine-5'-monophosphate | PoSSuM | |||
F89 | S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo(f)quinazolin-9-yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid | PoSSuM |
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Code | Name | Emphasize |
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Code | Name | Show |
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FMT | Formic acid |
Download interaction data: 1TLC
Structure summary
Code : | 1TLC PDBj RCSB PDB PDBe | ||||||||||||
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Header : | METHYLTRANSFERASE | ||||||||||||
Title : | THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89 | ||||||||||||
Release Data : | 1995-06-03 | ||||||||||||
Compound : |
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Source : |
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Authors : | Weichsel, A., Montfort, W.R., Ciesla, J., Maley, F. | ||||||||||||
Keywords : | METHYLTRANSFERASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.1 Å ) | ||||||||||||
Citation : |
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.
Weichsel, A.,Montfort, W.R.,Ciesla, J.
et al.
PubMed: 7724588 Structure, Multiple Site Binding, and Segmental Accommodation in Thymidylate Synthase on Binding Dump: And an Anti-Folate
Montfort, W.R.,Perry, K.M.,Fauman, E.B.
et al.
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Reaction
Chain : | A, B |
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UniProt : | P00470 (multiple entry names are found) |
Reaction : | - |