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Ligands
Code Name Style Show Link
DGP 2'-deoxyguanosine-5'-monophosphate
F89 S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo(f)quinazolin-9-yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid
Non-standard Residues
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Glycosylation
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FMT Formic acid
Code : 1TLC   PDBj   RCSB PDB   PDBe
Header : METHYLTRANSFERASE
Title : THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89
Release Data : 1995-06-03
Compound :
mol_id molecule chains
1 THYMIDYLATE SYNTHASE A,B
ec: 2.1.1.45
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
Authors : Weichsel, A., Montfort, W.R., Ciesla, J., Maley, F.
Keywords : METHYLTRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.

Weichsel, A.,Montfort, W.R.,Ciesla, J.  et al.
(1995)  Proc.Natl.Acad.Sci.USA  92 : 3493 - 3497

PubMed: 7724588
DOI: 10.1073/pnas.92.8.3493

Structure, Multiple Site Binding, and Segmental Accommodation in Thymidylate Synthase on Binding Dump: And an Anti-Folate

Montfort, W.R.,Perry, K.M.,Fauman, E.B.  et al.
(1990)  Biochemistry  29 : 6964

Chain : A, B
UniProt : P00470 (multiple entry names are found)
Reaction : -