Het-PDB Navi2 (PDB: 1TJI)

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Ligands
Code	Name		Style	Show	Link
EDO	1,2-ethanediol				PoSSuM
IPA	Isopropyl alcohol				PoSSuM

Non-standard Residues
Code	Name	Show
YCM	S-(2-amino-2-oxoethyl)-L-cysteine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
NH2	Amino group

Download interaction data: 1TJI

Code :

1TJI PDBj RCSB PDB PDBe

Header :

Viral protein/Immune system

Title :

Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 17mer epitope

Release Data :

2004-10-05

Compound :

mol_id	molecule	chains
1	anti-HIV-1 antibody 2F5 Light Chain	L

mol_id	molecule	chains
2	anti-HIV-1 antibody 2F5 Heavy Chain	H

mol_id	molecule	chains
3	Envelope Glycoprotein GP41	P
	fragment: Transmembrane Glycoprotein (residues 653-659)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	expression_system_common: Chinese hamster expression_system_cell_line: CB-F7 other_details: Heteromyeloma cell line fused with peripheral blood mononuclear cells

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	expression_system_common: Chinese hamster expression_system_cell_line: CB-F7 other_details: Heteromyeloma cell line fused with peripheral blood mononuclear cells

mol_id	organism_scientific
3
	synthetic: yes other_details: The peptide was chemically synthesized. The sequence of the peptide is naturally found in the human immunodeficiency virus (HIV-1; Strain JRFL).

Authors :

Ofek, G., Tang, M., Sambor, A., Katinger, H., Mascola, J.R., Wyatt, R., Kwong, P.D.

Keywords :

2F5, antibody, gp41, HIV-1, neutralizing, membrane-proximal, Viral protein-Immune system COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Structure and mechanistic analysis of the Anti-Human Immunodeficiency Virus type 1 antibody 2F5 in complex with its gp41 epitope

Ofek, G.,Tang, M.,Sambor, A. et al.
(2004) J.Virol. 78 : 10724 - 10737

PDB ID: 1TJI