Brand  (β version)

PDB ID: 1THL

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Ligands
Code Name Style Show Link
0DB N-({1-[(2s)-2-carboxy-4-phenylbutyl]cyclopentyl}carbonyl)-L-tryptophan PoSSuM
CA Calcium ion PoSSuM
ZN Zinc ion PoSSuM
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Structure summary

Code : 1THL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Thermolysin complexed with a novel glutaramide derivative, N-(1-(2(R,S)-carboxy-4-phenylbutyl) cyclopentylcarbonyl)-(S)-tryptophan
Release Data : 1994-01-31
Compound :
mol_id molecule chains
1 THERMOLYSIN A
ec: 3.4.24.27
Source :
mol_id organism_scientific
1 Bacillus thermoproteolyticus  (taxid:1427)
Authors : Holland, D.R., Matthews, B.W.
Keywords : METALLOPROTEINASE, GLUTARAMIDE DERIVATIVE, THERMOLYSIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Inhibition of Thermolysin and Neutral Endopeptidase 24.11 By a Novel Glutaramide Derivative; X-Ray Structure Determination of the Thermolysin-Inhibitor Complex

Holland, D.R.,Barclay, P.L.,Danilewicz, J.C.  et al.
(1994)  Biochemistry  33 : 51 - 56

PubMed: 8286362
DOI: 10.1021/bi00167a007

Binding of N-Carboxymethyl Dipeptide Inhibitors to Thermolysin Determined by X-Ray Crystallography: A Novel Class of Transition-State Analogues for Zinc Peptidases

Monzingo, A.F.,Matthews, B.W.
(1984)  Biochemistry  23 : 5724

Structure of Thermolysin Refined at 1.6 Angstroms Resolution

Holmes, M.A.,Matthews, B.W.
(1982)  J.Mol.Biol.  160 : 623

The Conformation of Thermolysin

Matthews, B.W.,Weaver, L.H.,Kester, W.R.
(1974)  J.Biol.Chem.  249 : 8030

Structure of Thermolysin

Matthews, B.W.,Colman, P.M.,Jansonius, J.N.  et al.
(1972)  Nature New Biol.  238 : 41

Three Dimensional Structure of Thermolysin

Matthews, B.W.,Jansonius, J.N.,Colman, P.N.  et al.
(1972)  Nature New Biol.  238 : 37

Reaction

Chain : A
UniProt : P00800 (THER_BACTH)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe. 3.4.24.27 -
-