Brand  (β version)

PDB ID: 1TDZ

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
FOX ((1r,2s,4r)-4-{[2-amino-5-(formylamino)-6-oxo-3,6-dihydropyrimidin-4-yl]amino}-2-hydroxycyclopentyl)methyl 5'-phosphate
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1TDZ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/DNA
Title : Crystal Structure Complex Between the Lactococcus Lactis FPG (Mutm) and a FAPY-dG Containing DNA
Release Data : 2004-09-07
Compound :
mol_id molecule chains
1 5'-D(*CP*TP*CP*TP*TP*TP*(FOX)P*TP*TP*TP*CP*TP*CP*G)-3' B
mol_id molecule chains
2 5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3' C
mol_id molecule chains synonym
3 formamidopyrimidine-DNA glycosylase A FAPY-DNA glycosylase
ec: 3.2.2.23
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific expression_system
3 Lactococcus lactis  (taxid:1358) Escherichia coli  (taxid:562)
gene: mutm, FPG
expression_system_vector_type: plasmid
expression_system_plasmid: pmal-C
Authors : Coste, F., Ober, M., Carell, T., Boiteux, S., Zelwer, C., Castaing, B.
Keywords : DNA REPAIR; FPG; MUTM; FAPY G, HYDROLASE-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by formamidopyrimidine-DNA glycosylase

Coste, F.,Ober, M.,Carell, T.  et al.
(2004)  J.Biol.Chem.  279 : 44074 - 44083

PubMed: 15249553
DOI: 10.1074/jbc.M405928200

Reaction

Chain : A
UniProt : P42371 (FPG_LACLC)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N- methyl)formamidopyrimidine. 3.2.2.23 -
-
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+) 4.2.99.18 -
-