Brand  (β version)

PDB ID: 1TBZ

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Ligands
Code Name Style Show Link
00Q D-phenylalanyl-N-{(1s)-1-[(S)-1,3-benzothiazol-2-yl(hydroxy)methyl]-4-carbamimidamidobutyl}-L-prolinamide PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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TYS O-sulfo-L-tyrosine
Glycosylation
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Structure summary

Code : 1TBZ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : HUMAN THROMBIN WITH ACTIVE SITE N-METHYL-D PHENYLALANYL-N-[5-(AMINOIMINOMETHYL)AMINO]-1-{{BENZOTHIAZOLYL)CARBONYL] BUTYL]-L-PROLINAMIDE TRIFLUROACETATE AND EXOSITE-HIRUGEN
Release Data : 1998-05-27
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN L
ec: 3.4.21.5
mol_id molecule chains
2 ALPHA-THROMBIN H
ec: 3.4.21.5
mol_id molecule chains
3 HIRUGEN I
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: PLASMA
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: PLASMA
mol_id organism_scientific organism_common
3 Hirudo medicinalis  (taxid:6421) Medicinal leech
Authors : Matthews, J.H., Krishnan, R., Costanzo, M.J., Maryanoff, B.E., Tulinsky, A.
Keywords : COMPLEX (SERINE PROTEASE-INHIBITOR), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.

Matthews, J.H.,Krishnan, R.,Costanzo, M.J.  et al.
(1996)  Biophys.J.  71 : 2830 - 2839

PubMed: 8913620

The Isomorphous Structures of Prethrombin2, Hirugen-, and Ppack-Thrombin: Changes Accompanying Activation and Exosite Binding to Thrombin

Vijayalakshmi, J.,Padmanabhan, K.P.,Mann, K.G.  et al.
(1994)  Protein Sci.  3 : 2254

Active Site and Exosite Binding of Alpha-Thrombin

Tulinsky, A.,Qiu, X.
(1993)  Blood Coagulation Fibrinolysis  4 : 305

Structure of the Hirulog 3-Thrombin Complex and Nature of the S' Subsites of Substrates and Inhibitors

Qiu, X.,Padmanabhan, K.P.,Carperos, V.E.  et al.
(1992)  Biochemistry  31 : 11689

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P09945 (HIRV2_HIRME)
Reaction : -