Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
1CS 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-L,3,5-triazin-2-yl)urea
FAD Flavin-adenine dinucleotide
K Potassium ion
MG Magnesium ion
NSP 5-(aminomethyl)-2-methylpyrimidin-4-amine
P22 Ethyl dihydrogen diphosphate
P25 Pentyl trihydrogen diphosphate
YF3 2-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}propane-1-thiol
Code : 1T9B
Title : Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron
Release Data : 2004-12-21
Compound :
mol_id molecule chains synonym
1 Acetolactate synthase, mitochondrial A,B Acetohydroxy-acid synthase, ALS, AHAS
fragment: Catalytic Subunit
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast Escherichia coli BL21(DE3)  (taxid:469008)
gene: ILV2, SMR1, YMR108W, YM9718.07
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET30(c)
Authors : McCourt, J.A., Pang, S.S., Guddat, L.W., Duggleby, R.G.
Keywords : acetohydroxyacid synthase, acetolactate synthase, herbicide, sulfonylurea, thiamin diphosphate, FAD, inhibitor, chlorsulfuron, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase.

McCourt, J.A.,Pang, S.S.,Guddat, L.W.  et al.
(2005)  Biochemistry  44 : 2330 - 2338

PubMed: 15709745
DOI: 10.1021/bi047980a

Chain : A, B
UniProt : P07342 (ILVB_YEAST)
Reaction : 2 pyruvate = 2-acetolactate + CO(2).