Het-PDB Navi2 (PDB: 1SZG)

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Ligands
Code	Name		Style	Show	Link
FNS	N-sulfo-flavin mononucleotide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1SZG

Code :

1SZG PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

A198G:L230A flavocytochrome b2 with sulfite bound

Release Data :

2004-07-27

Compound :

mol_id	molecule	chains	synonym
1	Cytochrome b2, mitochondrial	A,B	L-lactate dehydrogenase [Cytochrome]; L-lactate ferricytochrome C oxidoreductase; L-LCR
	ec: 1.1.2.3 fragment: residues 81-591 mutation: A198G:L230A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Saccharomyces cerevisiae (taxid:4932)	Baker's yeast	Escherichia coli (taxid:562)
	gene: CYB2 expression_system_strain: TG1 expression_system_vector_type: plasmid expression_system_plasmid: pDSb2

Authors :

Mowat, C.G., Wehenkel, A., Green, A.J., Walkinshaw, M.D., Reid, G.A., Chapman, S.K.

Keywords :

flavocytochrome; L-lactate dehydrogenase; sulfite, OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 2.70 Å )

Citation :

Altered Substrate Specificity in Flavocytochrome b(2): Structural Insights into the Mechanism of l-Lactate Dehydrogenation

Mowat, C.G.,Wehenkel, A.,Green, A.J. et al.
(2004) Biochemistry 43 : 9519 - 9526

Chain :

A, B

UniProt :

P00175 (CYB2_YEAST)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)	1.1.2.3	PubMed:11914072, PubMed:3004948, PubMed:4593578
	left-to-right	PubMed:3004948
Cofactor:	Evidence:	Note:
FMN	ECO:0000269 \| PubMed:11914072 ECO:0000269 \| PubMed:2329585	-
heme b	ECO:0000269 \| PubMed:11914072 ECO:0000269 \| PubMed:17563122 ECO:0000269 \| PubMed:2329585	Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.

PDB ID: 1SZG