Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
F89 S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo(f)quinazolin-9-yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid
UMP 2'-deoxyuridine 5'-monophosphate
Modified Residues
Code Name Link
FMT Formic acid
Code : 1SYN
Header : TRANSFERASE (METHYLTRANSFERASE)
Title : E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)
Release Data : 1996-01-29
Compound :
mol_id molecule chains
1 THYMIDYLATE SYNTHASE A,B
ec: 2.1.1.45
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
Authors : Stout, T.J., Stroud, R.M.
Keywords : TRANSFERASE (METHYLTRANSFERASE)
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.

Stout, T.J.,Stroud, R.M.
(1996)  Structure  4 : 67 - 77

PubMed: 8805515
DOI: 10.1016/S0969-2126(96)00010-X

Structure, Multiple Site Binding, and Segmental Accommodation in Thymidylate Synthase on Binding Dump and an Anti-Folate

Montfort, W.R.,Perry, K.M.,Fauman, E.B.  et al.
(1990)  Biochemistry  29 : 6964

Chain : A, B
UniProt : P0A884 (TYSY_ECOLI)
Reaction : 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.