Het-PDB Navi2 (PDB: 1SYN)

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Ligands
Code	Name		Style	Show	Link
F89	S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo(f)quinazolin-9-yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid				PoSSuM
UMP	2'-deoxyuridine 5'-monophosphate				PoSSuM

Non-standard Residues
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FMT	Formic acid

Download interaction data: 1SYN

Code :

1SYN PDBj RCSB PDB PDBe

Header :

TRANSFERASE (METHYLTRANSFERASE)

Title :

E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)

Release Data :

1996-01-29

Compound :

mol_id	molecule	chains
1	THYMIDYLATE SYNTHASE	A,B
	ec: 2.1.1.45

Source :

mol_id	organism_scientific
1	Escherichia coli (taxid:562)

Authors :

Stout, T.J., Stroud, R.M.

Keywords :

TRANSFERASE (METHYLTRANSFERASE)

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.

Stout, T.J.,Stroud, R.M.
(1996) Structure 4 : 67 - 77

Structure, Multiple Site Binding, and Segmental Accommodation in Thymidylate Synthase on Binding Dump and an Anti-Folate

Montfort, W.R.,Perry, K.M.,Fauman, E.B. et al.
(1990) Biochemistry 29 : 6964

Chain :

A, B

UniProt :

P0A884 (TYSY_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP	2.1.1.45	HAMAP-Rule:MF_00008, PubMed:2223754, PubMed:3286637, PubMed:9826509
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PDB ID: 1SYN