Brand  (β version)

PDB ID: 1SYH

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Ligands
Code Name Style Show Link
CPW (S)-2-amino-3-(1,3,5,7-pentahydro-2,4-dioxo-cyclopenta[E]pyrimidin-1-yl) proionic acid PoSSuM
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Structure summary

Code : 1SYH   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 1.85 A RESOLUTION.
Release Data : 2005-03-22
Compound :
mol_id molecule chains synonym
1 Glutamate receptor 2 A GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2
fragment: GLUR2-FLOP LIGAND-BINDING CORE (S1S2J)
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli BL21(DE3)  (taxid:469008)
gene: GRIA2, GLUR2
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET30B
Authors : Frandsen, A., Pickering, D.S., Vestergaard, B., Kasper, C., Nielsen, B.B., Greenwood, J.R., Campiani, G., Gajhede, M., Schousboe, A., Kastrup, J.S.
Keywords : IONOTROPIC GLUTAMATE RECEPTOR GLUR2, LIGAND-BINDING CORE, AGONIST COMPLEX, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2.

Frandsen, A.,Pickering, D.S.,Vestergaard, B.  et al.
(2005)  Mol.Pharmacol.  67 : 703 - 713

PubMed: 15591246
DOI: 10.1124/mol.104.002931

STRUCTURAL BASIS FOR AMPA RECEPTOR ACTIVATION AND LIGAND SELECTIVITY: CRYSTAL STRUCTURES OF FIVE AGONIST COMPLEXES WITH THE GLUR2 LIGAND BINDING CORE.

HOGNER, A.,KASTRUP, J.S.,JIN, R.  et al.
(2002)  J.Mol.Biol.  322 : 93

DOI: 10.1016/S0022-2836(02)00650-2

MECHANISMS FOR ACTIVATION AND ANTAGONISM OF AN AMPA-SENSITIVE GLUTAMATE RECEPTOR: CRYSTAL STRUCTURES OF THE GLUR2 LIGAND BINDING CORE.

ARMSTRONG, N.,GOUAUX, E.
(2000)  NEURON  28 : 165

DOI: 10.1016/S0896-6273(00)00094-5

PROBING THE LIGAND BINDING DOMAIN OF THE GLUR2 RECEPTOR BY PROTEOLYSIS AND DELETION MUTAGENESIS DEFINES DOMAIN BOUNDARIES AND YIELDS A CRYSTALLIZABLE CONSTRUCT.

CHEN, G.Q.,SUN, R.,JIN, R.  et al.
(1998)  Protein Sci.  7 : 2623

Reaction

Chain : A
UniProt : P19491 (GRIA2_RAT)
Reaction : -