Het-PDB Navi2 (PDB: 1SUO)

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Ligands
Code	Name		Style	Show	Link
CPZ	4-(4-chlorophenyl)imidazole				PoSSuM
HEM	Protoporphyrin ix containing Fe				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1SUO

Code :

1SUO PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Structure of mammalian cytochrome P450 2B4 with bound 4-(4-chlorophenyl)imidazole

Release Data :

2004-07-20

Compound :

mol_id	molecule	chains	synonym
1	Cytochrome P450 2B4	A	CYPIIB4, P450-LM2, Isozyme 2, P450 types B0 and B1
	ec: 1.14.14.1 mutation: E2A, G22K, H23K, P24T, K25S, A26S, H27K, R29K, P221S, H226Y other_details: CYS 436 BINDS HEME IRON. 4-(4-CHLOROPHENYL)IMIDAZOLE IS BOUND IN THE ACTIVE SITE COORDINATING TO THE HEME IRON AS THE SIXTH LIGAND.

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Oryctolagus cuniculus (taxid:9986)	Rabbit	Escherichia coli (taxid:562)
	gene: CYP2B4 expression_system_strain: TOPP3 expression_system_vector_type: plasmid expression_system_plasmid: PKK

Authors :

Scott, E.E., White, M.A., He, Y.A., Johnson, E.F., Stout, C.D., Halpert, J.R.

Keywords :

oxidoreductase, membrane protein, CYP 2B4, CYP LM2, Cytochrome p450, Monooxygenase

Exp. method :

X-RAY DIFFRACTION ( 1.9 Å )

Citation :

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9 {angstrom} resolution: Insight into the range of P450 conformations and coordination of redox partner binding.

Scott, E.E.,White, M.A.,He, Y.A. et al.
(2004) J.Biol.Chem. 279 : 27294 - 27301

PubMed: 15100217
DOI: 10.1074/jbc.M403349200

An Open Conformation of Mammalian Cytochrome P450 2B4 at 1.6 A Resolution

Scott, E.E.,He, Y.A.,Wester, M.R. et al.
(2003) Proc.Natl.Acad.Sci.USA 100 : 13196 - 13201

DOI: 10.1073/pnas.2133986100

A Truncation of 2B Subfamily Cytochromes P450 Yields Increased Expression Levels, Increased Solubility, and Decreased Aggregation While Retaining Function

Scott, E.E.,Spatzenegger, M.,Halpert, J.R.
(2001) Arch.Biochem.Biophys. 395 : 57 - 68

DOI: 10.1006/abbi.2001.2574

Chain :

UniProt :

P00178 (CP2B4_RABIT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]	1.14.14.1	-
	-	-

PDB ID: 1SUO

Hetero Atom Contents

Structure summary

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