Brand  (β version)

PDB ID: 1SOO

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Ligands
Code Name Style Show Link
BME Beta-mercaptoethanol PoSSuM
H5P Hydantocidin-5'-phosphate PoSSuM
NA Sodium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1SOO   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : ADENYLOSUCCINATE SYNTHETASE INHIBITED BY HYDANTOCIDIN 5'-MONOPHOSPHATE
Release Data : 1997-09-04
Compound :
mol_id molecule chains
1 ADENYLOSUCCINATE SYNTHETASE A
ec: 6.3.4.4
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
strain: PUR A STRAIN H1238
Authors : Cowan-Jacob, S.W.
Keywords : PURINE NUCLEOTIDE BIOSYNTHESIS, GTP-HYDROLYZING ENZYME, HERBICIDE, LIGASE, SYNTHETASE
Exp. method : X-RAY DIFFRACTION ( 2.6 Å )
Citation :

The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase.

Fonne-Pfister, R.,Chemla, P.,Ward, E.  et al.
(1996)  Proc.Natl.Acad.Sci.USA  93 : 9431 - 9436

PubMed: 8790347
DOI: 10.1073/pnas.93.18.9431

Refined Crystal Structures of Unligated Adenylosuccinate Synthetase from Escherichia Coli

Silva, M.M.,Poland, B.W.,Hoffman, C.R.  et al.
(1995)  J.Mol.Biol.  254 : 431

Crystal Structure of Adenylosuccinate Synthetase from Escherichia Coli. Evidence for Convergent Evolution of GTP-Binding Domains

Poland, B.W.,Silva, M.M.,Serra, M.A.  et al.
(1993)  J.Biol.Chem.  268 : 25334

Preliminary X-Ray Crystallographic Study of Adenylosuccinate Synthetase from Escherichia Coli

Serra, M.A.,Bass, M.B.,Fromm, H.J.  et al.
(1988)  J.Mol.Biol.  200 : 753

Reaction

Chain : A
UniProt : P0A7D4 (PURA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2- dicarboxyethyl)-AMP + phosphate 6.3.4.4 HAMAP- Rule:MF_00011
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