Brand  (β version)

PDB ID: 1SM8

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Ligands
Code Name Style Show Link
CR Chromium ion PoSSuM
DUT Deoxyuridine-5'-triphosphate PoSSuM
NO3 Nitrate ion PoSSuM
TRS 2-amino-2-hydroxymethyl-propane-1,3-diol PoSSuM
Non-standard Residues
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Structure summary

Code : 1SM8   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : M. tuberculosis dUTPase complexed with chromium and dUTP
Release Data : 2004-03-16
Compound :
mol_id molecule chains synonym
1 Deoxyuridine 5'-triphosphate nucleotidohydrolase A,B,C dUTPase, dUTP pyrophosphatase
ec: 3.6.1.23
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
gene: DUT, RV2697C, MT2771, MTCY05A6.18C, MB2716C
expression_system_strain: BL21PRO
expression_system_vector_type: plasmid
expression_system_plasmid: modified pET28b
Authors : Sawaya, M.R., Chan, S., Segelke, B., Lekin, T., Krupka, H., Cho, U.S., Kim, M.-Y., So, M., Kim, C.-Y., Naranjo, C.M., Rogers, Y.C., Park, M.S., Waldo, G.S., Pashkov, I., Cascio, D., Yeates, T.O., Perry, J.L., Terwilliger, T.C., Eisenberg, D., TB Structural Genomics Consortium (TBSGC)
Keywords : jelly-roll, Structural Genomics, PSI, Protein Structure Initiative, TB Structural Genomics Consortium, TBSGC, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism.

Chan, S.,Segelke, B.,Lekin, T.  et al.
(2004)  J.Mol.Biol.  341 : 503 - 517

PubMed: 15276840
DOI: 10.1016/j.jmb.2004.06.028

Reaction

Chain : A, B, C
UniProt : P0A552 (DUT_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
dUTP + H2O = dUMP + diphosphate + H(+) 3.6.1.23 HAMAP-Rule:MF_00116, PubMed:15276840
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000255 | HAMAP-Rule:MF_00116
ECO:0000269 | PubMed:15276840
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