Het-PDB Navi2 (PDB: 1SM2)

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Ligands
Code	Name		Style	Show	Link
STU	Staurosporine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1SM2

Code :

1SM2 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain

Release Data :

2004-07-16

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase ITK/TSK	A,B	T-cell-specific kinase, Tyrosine-protein kinase Lyk, Kinase EMT
	ec: 2.7.1.112 fragment: catalytic kinase domain

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: ITK, LYK, EMT

Authors :

Brown, K., Long, J.M., Vial, S.C.M., Dedi, N., Dunster, N.J., Renwick, S.B., Tanner, A.J., Frantz, J.D., Fleming, M.A., Cheetham, G.M.T.

Keywords :

Protein Kinase, Immunology, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.

Brown, K.,Long, J.M.,Vial, S.C. et al.
(2004) J.Biol.Chem. 279 : 18727 - 18732

Chain :

A, B

UniProt :

Q08881 (ITK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028
	-	PROSITE-ProRule:PRU10028

PDB ID: 1SM2