Brand  (β version)

PDB ID: 1SK0

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Ligands
Code Name Style Show Link
CS Cesium ion PoSSuM
SO4 Sulfate ion PoSSuM
TAS Trihydroxyarsenite(III) PoSSuM
Non-standard Residues
Code Name Show
CZ2 S-(dihydroxyarsino)cysteine
Glycosylation
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Structure summary

Code : 1SK0   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : ARSENATE REDUCTASE R60A MUTANT +0.4M ARSENITE FROM E. COLI
Release Data : 2005-03-15
Compound :
mol_id molecule chains synonym
1 Arsenate reductase A Arsenical pump modifier
ec: 1.20.4.1
mutation: R60A
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
Authors : Demel, S., Edwards, B.F.
Keywords : ARSC, REDUCTASE, ARSENITE, ARSENATE, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Arginine 60 in the ArsC arsenate reductase of E. coli plasmid R773 determines the chemical nature of the bound As(III) product.

DeMel, S.,Shi, J.,Martin, P.  et al.
(2004)  Protein Sci.  13 : 2330 - 2340

PubMed: 15295115
DOI: 10.1110/ps.04787204

Reaction

Chain : A
UniProt : P08692 (ARSC1_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
[glutaredoxin]-dithiol + arsenate + glutathione + H(+) = arsenite + glutathionyl-S-S-[glutaredoxin] + H2O 1.20.4.1 PubMed:14592722, PubMed:7577935, PubMed:8003492
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