Het-PDB Navi2 (PDB: 1SHL)

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Ligands
Code	Name		Style	Show	Link
FXN	5-fluoro-1h-indole-2-carboxylic acid-(2-mercapto-ethyl)-amide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1SHL

Code :

1SHL PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

CASPASE-7 IN COMPLEX WITH FICA ALLOSTERIC INHIBITOR

Release Data :

2004-08-17

Compound :

mol_id	molecule	chains	synonym
1	Caspase-7	A,B	ICE-like apoptotic protease 3, ICE-LAP3, Apoptotic protease Mch-3, CMH-1
	ec: 3.4.22.- mutation: D192A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: CASP7, MCH3 expression_system_strain: BL21 (DE3) expression_system_vector_type: plasmid expression_system_plasmid: pJH07, pJH08 other_details: Caspase-7 large and small subunits were co-expressed from two separate plasmids , yielding a large subunit of residues 57-199 and a small subunit of residues 21 0-303 with the addition of eight amino acids QLHHHHHH.

Authors :

Hardy, J.A., Lam, J., Nguyen, J.T., O'Brien, T., Wells, J.A.

Keywords :

caspase, protease, cysteine protease, allosteric, central-cavity, dimer interface, inhibitor, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 3.00 Å )

Citation :

Discovery of an allosteric site in the caspases

Hardy, J.A.,Lam, J.,Nguyen, J.T. et al.
(2004) Proc.Natl.Acad.Sci.USA 101 : 12461 - 12466

Chain :

A, B

UniProt :

P55210 (CASP7_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-\|-.	3.4.22.60	PubMed:10497198, PubMed:11257230, PubMed:11701129, PubMed:12824163, PubMed:16123041, PubMed:16374543, PubMed:16916640, PubMed:17646170, PubMed:17697120, PubMed:18723680, PubMed:19581639, PubMed:19617626, PubMed:20566630, PubMed:22451931, PubMed:23650375, PubMed:23897474, PubMed:27032039, PubMed:31586028, PubMed:34156061
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PDB ID: 1SHL