Het-PDB Navi2 (PDB: 1SD1)

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Ligands
Code	Name		Style	Show	Link
FMC	(1s)-1-(7-amino-1h-pyrazolo[4,3-D]pyrimidin-3-yl)-1,4-anhydro-D-ribitol				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1SD1

Code :

1SD1 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH FORMYCIN A

Release Data :

2004-05-18

Compound :

mol_id	molecule	chains	synonym
1	5'-methylthioadenosine phosphorylase	A	MTA phosphorylase, MTAPase
	ec: 2.4.2.28

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: MTAP, MSAP expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: PET-28A

Authors :

Lee, J.E., Settembre, E.C., Cornell, K.A., Riscoe, M.K., Sufrin, J.R., Ealick, S.E., Howell, P.L.

Keywords :

METHYLTHIOADENOSINE PHOSPHORYLASE, PURINE NUCLEOSIDE PHOSPHORYLASE, PURINE SALVAGE, FORMYCIN A, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.03 Å )

Citation :

Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design.

Lee, J.E.,Settembre, E.C.,Cornell, K.A. et al.
(2004) Biochemistry 43 : 5159 - 5169

PubMed: 15122881
DOI: 10.1021/bi035492h

Chain :

UniProt :

Q13126 (MTAP_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5- thio-alpha-D-ribose 1-phosphate	2.4.2.28	HAMAP- Rule:MF_03155
	-	HAMAP- Rule:MF_03155

PDB ID: 1SD1

Hetero Atom Contents

Structure summary

Reaction