Het-PDB Navi2 (PDB: 1SA4)

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Ligands
Code	Name		Link
FPP	Farnesyl diphosphate		PoSSuM
JAN	6-[(S)-amino(4-chlorophenyl)(1-methyl-1h-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1h)-one		PoSSuM
ZN	Zinc ion		PoSSuM
FRU	Beta-D-fructofuranose		PoSSuM
GLC	Alpha-D-glucopyranose		PoSSuM
		: Polysaccharide

Non-standard Residues
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Glycosylation
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Download interaction data: 1SA4

Code :

1SA4 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

human protein farnesyltransferase complexed with FPP and R115777

Release Data :

2004-06-08

Compound :

mol_id	molecule	chains	synonym
1	Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit	A	CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase alpha subunit, GGTase-I-alpha
	ec: 2.5.1.58, 2.5.1.59

mol_id	molecule	chains	synonym
2	Protein farnesyltransferase beta subunit	B	CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta
	ec: 2.5.1.58

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: FNTA

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: FNTB

Authors :

Reid, T.S., Beese, L.S.

Keywords :

FTASE, FARNESYLTRANSFERASE, FARNESYL TRANSFERASE, CAAX, RAS, CANCER, TUMOR REGRESSION, R115777, TIPIFARNIB, ZARNESTRA, FTI, CLINICAL CANDIDATE, INHIBITOR, PROTEIN PRENYLATION, LIPID MODIFICATION, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI Selectivity.

Reid, T.S.,Beese, L.S.
(2004) Biochemistry 43 : 6877 - 6884

PubMed: 15170324
DOI: 10.1021/bi049723b

Chain :

UniProt :

P49354 (FNTA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S- (2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate	2.5.1.58	PubMed:12036349, PubMed:12825937, PubMed:16893176, PubMed:19246009, PubMed:8419339, PubMed:8494894
	-
geranylgeranyl diphosphate + L-cysteinyl-[protein] = S- geranylgeranyl-L-cysteinyl-[protein] + diphosphate	2.5.1.59	PubMed:16893176
	-	PubMed:16893176
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000250 \| UniProtKB:P29703	-

Chain :

UniProt :

P49356 (FNTB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S- (2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate	2.5.1.58	PubMed:12036349, PubMed:12825937, PubMed:16893176, PubMed:19246009, PubMed:8494894
	-
Cofactor:	Evidence:	Note:
Zn(2+)	ECO:0000269 \| PubMed:11687658 ECO:0000269 \| PubMed:12036349 ECO:0000269 \| PubMed:12825937 ECO:0000269 \| PubMed:15451670 ECO:0000269 \| PubMed:16893176 ECO:0000269 \| PubMed:19246009	Binds 1 zinc ion per subunit.

PDB ID: 1SA4

Hetero Atom Contents

Structure summary

Reaction