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Ligands
Code Name Style Show Link
778 4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1h-imidazol-1-yl)methyl]benzonitrile
FPP Farnesyl diphosphate
ZN Zinc ion
FRU Beta-D-fructofuranose
GLC Alpha-D-glucopyranose
: Polysaccharide
Non-standard Residues
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Glycosylation
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Code : 1S63   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human protein farnesyltransferase complexed with L-778,123 and FPP
Release Data : 2004-07-27
Compound :
mol_id molecule chains synonym
1 Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit A CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase alpha subunit, GGTase-I-alpha
ec: 2.5.1.58, 2.5.1.59
fragment: ALPHA SUBUNIT
mol_id molecule chains synonym
2 Protein farnesyltransferase beta subunit B CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta
ec: 2.5.1.58
fragment: BETA SUBUNIT
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
organ: BRAIN
gene: FNTA
expression_system_atcc_number: 63134
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
organ: BRAIN
gene: FNTB
expression_system_atcc_number: 63134
Authors : Long, S.B., Casey, P.J., Beese, L.S.
Keywords : FARNESYLTRANSFERASE, FTASE, GERANYLGERANYLTRANSFERASE, CANCER, CAAX, FTI, INHIBITOR, RAS, LIPID MODIFICATION, PROTEIN PRENYLATION, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes.

Reid, T.S.,Long, S.B.,Beese, L.S.
(2004)  Biochemistry  43 : 9000 - 9008

PubMed: 15248757
DOI: 10.1021/bi049280b

Chain : A
UniProt : P49354 (FNTA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12036349, PubMed:12825937, PubMed:16893176, PubMed:19246009, PubMed:8419339, PubMed:8494894
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geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.59 PubMed:16893176
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Chain : B
UniProt : P49356 (FNTB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12036349, PubMed:12825937, PubMed:16893176, PubMed:19246009, PubMed:8494894
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