PDB ID: 1S63
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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778 | 4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1h-imidazol-1-yl)methyl]benzonitrile | PoSSuM | |||
FPP | Farnesyl diphosphate | PoSSuM | |||
ZN | Zinc ion | PoSSuM | |||
FRU | Beta-D-fructofuranose | PoSSuM | |||
GLC | Alpha-D-glucopyranose | PoSSuM | |||
: Polysaccharide |
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Download interaction data: 1S63
Structure summary
Code : | 1S63 PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | TRANSFERASE | ||||||||||||||||||||||||
Title : | Human protein farnesyltransferase complexed with L-778,123 and FPP | ||||||||||||||||||||||||
Release Data : | 2004-07-27 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Long, S.B., Casey, P.J., Beese, L.S. | ||||||||||||||||||||||||
Keywords : | FARNESYLTRANSFERASE, FTASE, GERANYLGERANYLTRANSFERASE, CANCER, CAAX, FTI, INHIBITOR, RAS, LIPID MODIFICATION, PROTEIN PRENYLATION, TRANSFERASE | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.90 Å ) | ||||||||||||||||||||||||
Citation : |
Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes.
Reid, T.S.,Long, S.B.,Beese, L.S.
PubMed: 15248757 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | P49354 (FNTA_HUMAN) | ||||||||||||
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Chain : | B | ||||||||
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UniProt : | P49356 (FNTB_HUMAN) | ||||||||
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