Brand  (β version)

PDB ID: 1S3Z

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
COA Coenzyme a PoSSuM
NI Nickel (II) ion PoSSuM
RIO Ribostamycin PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1S3Z   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and Ribostamycin
Release Data : 2004-05-18
Compound :
mol_id molecule chains synonym
1 aminoglycoside 6'-N-acetyltransferase A,B Aminoglycoside N-Acetyltransferase AAC(6')-Iy
ec: 2.3.1.82
Source :
mol_id organism_scientific expression_system
1 Salmonella enteritidis  (taxid:592) Escherichia coli  (taxid:562)
expression_system_vector_type: plasmid
expression_system_plasmid: pet28a+
Authors : Vetting, M.W., Magnet, S., Nieves, E., Roderick, S.L., Blachard, J.S.
Keywords : GNAT, N-acetyltransferase, acetyltransferase, aminoglycoside, CoA, ribostamycin, transferase
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones

Vetting, M.W.,Magnet, S.,Nieves, E.  et al.
(2004)  Chem.Biol.  11 : 565 - 573

PubMed: 15123251
DOI: 10.1016/j.chembiol.2004.03.017

Kinetic and mutagenic characterization of the chromosomally encoded Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase

Magnet, S.,Lambert, T.,Courvalin, P.  et al.
(2001)  Biochemistry  40 : 3700 - 3709

DOI: 10.1021/bi002736e

Reaction

Chain : A, B
UniProt : Q9R381 (AAC6_SALEN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B 2.3.1.82 PubMed:10542165, PubMed:15123251, PubMed:18095712
-