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Ligands
Code Name Style Show Link
C3S Cholest-5-en-3-yl hydrogen sulfate
Non-standard Residues
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Glycosylation
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Code : 1S0X   PDBj   RCSB PDB   PDBe
Header : hormone/growth factor receptor
Title : Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2A
Release Data : 2004-02-10
Compound :
mol_id molecule chains synonym
1 Nuclear receptor ROR-alpha A Nuclear receptor RZR-alpha
fragment: ligand binding domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: RORA, NR1F1, RZRA
expression_system_common: Fall armyworm
expression_system_strain: SF9
expression_system_vector_type: bacculovirus
Authors : Kallen, J., Schlaeppi, J.M., Bitsch, F., Delhon, I., Fournier, B.
Keywords : THREE-LAYERED ALPHA HELICAL SANDWICH, NUCLEAR HORMONE RECEPTOR, ORPHAN RECEPTOR, LIGAND BINDING DOMAIN, hormone-growth factor receptor COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A

Kallen, J.,Schlaeppi, J.M.,Bitsch, F.  et al.
(2004)  J.Biol.Chem.  279 : 14033 - 14038

PubMed: 14722075
DOI: 10.1074/jbc.M400302200

X-ray structure of the hRORalpha LBD at 1.63A: Structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

Kallen, J.,Schlaeppi, J.-M.,Bitsch, F.  et al.
(2002)  Structure  10 : 1697 - 1707

DOI: 10.1016/S0969-2126(02)00912-7

Chain : A
UniProt : P35398 (RORA_HUMAN)
Reaction : -