Brand  (β version)

PDB ID: 1S0M

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Ligands
Code Name Style Show Link
BAP 1,2,3-trihydroxy-1,2,3,4-tetrahydrobenzo[a]pyrene PoSSuM
MG Magnesium ion PoSSuM
CA Calcium ion PoSSuM
DTP 2'-deoxyadenosine 5'-triphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1S0M   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : Crystal structure of a Benzo[a]pyrene Diol Epoxide adduct in a ternary complex with a DNA polymerase
Release Data : 2004-03-30
Compound :
mol_id molecule chains
1 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*T)-3' C,E
mol_id molecule chains
2 5'-D(P*AP*TP*AP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*CP*A)-3' D,F
mol_id molecule chains synonym
3 DNA polymerase IV A,B Pol IV
ec: 2.7.7.7
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific expression_system
3 Sulfolobus solfataricus  (taxid:273057) Escherichia coli  (taxid:562)
strain: P2
gene: DPO4
expression_system_vector_type: PLASMID
expression_system_plasmid: PET22B
Authors : Ling, H., Sayer, J.M., Boudsocq, F., Plosky, B.S., Woodgate, R., Yang, W.
Keywords : Benzo pyrene, Carcinogen, LESION BYPASS, POLYMERASE, TRANSFERASE-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.7 Å )
Citation :

Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase.

Ling, H.,Sayer, J.M.,Plosky, B.S.  et al.
(2004)  Proc.Natl.Acad.Sci.USA  101 : 2265 - 2269

PubMed: 14982998
DOI: 10.1073/pnas.0308332100

Reaction

Chain : A, B
UniProt : Q97W02 (DPO4_SACS2)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 -
-