PDB ID: 1RTL
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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CPX | N-[(2r,3s)-1-((2s)-2-{[(cyclopentylamino)carbonyl]amino}-3-methylbutanoyl)-2-(1-formyl-1-cyclobutyl)pyrrolidinyl]cyclopropanecarboxamide | PoSSuM | |||
ZN | Zinc ion | PoSSuM |
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Download interaction data: 1RTL
Structure summary
Code : | 1RTL PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | Viral protein complex | ||||||||||||||||||||||||
Title : | CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN: NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND PYRROLIDINE-5,5-TRANSLACTAM INHIBITOR | ||||||||||||||||||||||||
Release Data : | 2004-12-14 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Skarzynski, T., Somers, D.O.N. | ||||||||||||||||||||||||
Keywords : | VIRAL PROTEIN, SERINE PROTEASE, NONSTRUCTURAL PROTEIN, COFACTOR PEPTIDE, HELICASE, INHIBITOR, TRANSLACTAM, Viral protein complex | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.75 Å ) | ||||||||||||||||||||||||
Citation : |
Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease
Slater, M.J.,Amphlett, E.M.,Andrews, D.M.
et al.
PubMed: 14627400 Pyrrolidine-5,5-Trans-Lactams. 2. The Use of X-Ray Crystal Structure Data in the Optimisation of P3 and P4 Substituents
Andrews, D.M.,Chaignot, H.,Coomber, B.A.
et al.
DOI: 10.1021/ol027014p |
Reaction
Chain : | A, B | ||||||||
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UniProt : | Q91RS4 (Q91RS4_9HEPC) | ||||||||
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