Brand  (β version)

PDB ID: 1RRW

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
9MG 9-methylguanine PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1RRW   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : DHNA complexed with 9-methylguanine
Release Data : 2004-03-30
Compound :
mol_id molecule chains synonym
1 Dihydroneopterin aldolase A DHNA
ec: 4.1.2.25
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus  (taxid:1280) Escherichia coli  (taxid:562)
gene: FOLB
Authors : Sanders, W.J., Nienaber, V.L., Lerner, C.G., McCall, J.O., Merrick, S.M., Swanson, S.J., Harlan, J.E., Stoll, V.S., Stamper, G.F., Betz, S.F., Condroski, K.R., Meadows, R.P., Severin, J.M., Walter, K.A., Magdalinos, P., Jakob, C.G., Wagner, R., Beutel, B.A.
Keywords : DHNA complexed with 9-methylguanine, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.21 Å )
Citation :

Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.

Sanders, W.J.,Nienaber, V.L.,Lerner, C.G.  et al.
(2004)  J.Med.Chem.  47 : 1709 - 1718

PubMed: 15027862
DOI: 10.1021/jm030497y

Reaction

Chain : A
UniProt : P56740 (FOLB_STAAU)
Reaction: EC: Evidence:
Physiological Direction:
7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde 4.1.2.25 PubMed:9586996
-
7,8-dihydroneopterin = 7,8-dihydromonapterin 5.1.99.8 UniProtKB:P0AC16
-