Brand  (β version)

PDB ID: 1RQI

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Ligands
Code Name Style Show Link
DPO Diphosphate PoSSuM
DST Dimethylallyl S-thiolodiphosphate PoSSuM
IPR Isopentyl pyrophosphate PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1RQI   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Dimethylallyl S-Thiolodiphosphate
Release Data : 2004-03-02
Compound :
mol_id molecule chains synonym
1 Geranyltranstransferase A,B Farnesyl-diphosphate synthase, FPP synthase
ec: 2.5.1.10
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: ISPA, B0421
Authors : Hosfield, D.J., Zhang, Y., Dougan, D.R., Brooun, A., Tari, L.W., Swanson, R.V., Finn, J.
Keywords : isoprenyl synthase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.42 Å )
Citation :

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

Hosfield, D.J.,Zhang, Y.,Dougan, D.R.  et al.
(2004)  J.Biol.Chem.  279 : 8526 - 8529

PubMed: 14672944
DOI: 10.1074/jbc.C300511200

Reaction

Chain : A, B
UniProt : P22939 (ISPA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 -
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:14672944
Binds 2 Mg(2+) ions per subunit.