Het-PDB Navi2 (PDB: 1RO6)

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Ligands
Code	Name	Link
ZN	Zinc ion	PoSSuM
MN	Manganese (II) ion	PoSSuM
ARS	Arsenic	PoSSuM
ROL	Rolipram	PoSSuM

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Glycosylation
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Download interaction data: 1RO6

Code :

1RO6 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of PDE4B2B complexed with Rolipram (R & S)

Release Data :

2004-12-07

Compound :

mol_id	molecule	chains	synonym
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	A,B	DPDE4, PDE32, PDE4B2B
	ec: 3.1.4.17 fragment: catalytic domain mutation: S487A, S489A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Unidentified baculovirus (taxid:10469)
	gene: PDE4B

Authors :

Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.

Keywords :

PDE, Rolipram, crystal, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.

Xu, R.X.,Rocque, W.J.,Lambert, M.H. et al.
(2004) J.Mol.Biol. 337 : 355 - 365

Chain :

A, B

UniProt :

Q07343 (PDE4B_HUMAN)

PDB ID: 1RO6