Brand  (β version)

PDB ID: 1RL8

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Ligands
Code Name Style Show Link
RIT Ritonavir PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1RL8   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir
Release Data : 2005-04-19
Compound :
mol_id molecule chains synonym
1 protease RETROPEPSIN A,B HIV-1 PROTEASE
ec: 3.4.23.16
mutation: V82A
other_details: complexed with ritonavir
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli BL21(DE3)  (taxid:469008)
gene: gag-pol
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: p566
Authors : Rezacova, P., Brynda, J., Sedlacek, J., Konvalinka, J., Fabry, M., Horejsi, M.
Keywords : ASPARTIC PROTEASE, ASPARTIC PROTEASE-INHIBITOR COMPLEX, RESISTANT STRAIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir

Rezacova, P.,Brynda, J.,Sedlacek, J.  et al.
(2005)  To be Published 

Reaction

Chain : A, B
UniProt : P03367 (POL_HV1BR)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 -
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 -
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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