Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
BR Bromide ion
HO Holmium atom
BMA Beta-D-mannose
FUC Alpha-L-fucose
FUL Beta-L-fucose
MAN Alpha-D-mannose
NAG N-acetyl-D-glucosamine
NDG 2-(acetylamino)-2-deoxy-a-D-glucopyranose
PO4 Phosphate ion
Code : 1RER
Header : VIRAL PROTEIN
Title : Crystal structure of the homotrimer of fusion glycoprotein E1 from Semliki Forest Virus.
Release Data : 2004-01-27
Compound :
mol_id molecule chains
1 Structural polyprotein A,B,C
fragment: Spike glycoprotein E1
other_details: Contains: Coat protein C (EC 3.4.21.-) (Capsid protein C); Spike glycoprotein E3; Spike glycoprotein E2; Spike glycoprotein E1
Source :
mol_id organism_scientific
1 Semliki forest virus  (taxid:11033)
Authors : Gibbons, D.L., Vaney, M.C., Roussel, A., Vigouroux, A., Reilly, B., Kielian, M., Rey, F.A.
Keywords : Envelope glycoprotein, Membrane fusion, virus., Viral protein
Exp. method : X-RAY DIFFRACTION ( 3.2 Å )
Citation :

Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus.

Gibbons, D.L.,Vaney, M.C.,Roussel, A.  et al.
(2004)  Nature  427 : 320 - 325

PubMed: 14737160
DOI: 10.1038/nature02239

THE FUSION GLYCOPROTEIN SHELL OF SEMLIKI FOREST VIRUS: AN ICOSAHEDRAL ASSEMBLY PRIMED FOR FUSOGENIC ACTIVATION AT ENDOSOMAL PH

LESCAR, J.,ROUSSEL, A.,WIEN, M.W.  et al.
(2001)  Cell(Cambridge,Mass.)  105 : 137 - 148

DOI: 10.1016/S0092-8674(01)00303-8

Visualization of the target-membrane-inserted fusion protein of Semliki Forest virus by combined electron microscopy and crystallography.

Gibbons, D.L.,Erk, I.,Reilly, B.  et al.
(2003)  Cell(Cambridge,Mass.)  114 : 573 - 583

DOI: 10.1016/S0092-8674(03)00683-4

Molecular dissection of the Semliki Forest virus homotrimer reveals two functionally distinct regions of the fusion protein.

Gibbons, D.L.,Lepault, J.
(2002)  J.VIROL.  76 : 1194 - 1205

Chain : A, B, C
UniProt : P03315 (POLS_SFV)
Reaction : Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.